Agricultural Research,Education and Extension Organization Iranian Journal of Fisheries Sciences 1562-2916 6 2 2007 01 01 Study on the potency of domperidone and metoclopramide for spawning induction in Kutum (Rutilus frisii kutum ) 105 118 114789 10.22092/ijfs.2018.114789 EN F. Peykan Heyrati S. Dorafshan Journal Article 2018 01 02 The effectiveness of two kinds of dopamine antagonist (DA), metoclopramide (Met) and domperidone (Dom) combined with the gonadotropin releasing hormone analogue (D-Ala6, Des Gly10 ethylamide) GnRHa was assayed on the ovulation success, latency period, ovulation index (OI) and fertilization success of kutum, Rutilus frisii kutum (Kamenskii, 1901). Brood fish were injected intra-peritoneally as follows: 2 mg/kg b.w. of carp pituitary extract (CPE) as a control, 5 g+ 2.5mg, 1mg+ 5mg and 2mg+ 10mg/kg b.w. of GnRHa + Met or Dom in a single injection. Based on the ovulation and fertilization success, no significant differences between similar doses of Dom and Met when combined with similar doses of GnRHa were found (p>0.05). However, in some groups, the OI and latency period were greater when Dom was used as a DA instead of Met (p<0.05). In general, the results of this study showed that the potency of Dom was nearly same as Met when combined with GnRHa and used as a DA in kutum. It is strongly recommended to repeat the experiment under different conditions to find out definite conclusion. https://jifro.areeo.ac.ir/article_114789_8716afe708b527c53cda20c786d909df.pdf