Agricultural Research,Education and Extension Organization Iranian Journal of Fisheries Sciences 1562-2916 24 1 2025 11 01 Arthrospira platensis supplementation: A nutritional boost for enhancing survival and hemato-biochemical indices of Persian Sturgeon (Acipenser persicus) larvae 69 83 132434 10.22092/ijfs.2024.132434 EN M. Akhoundian Department of Marine Biology, Faculty of Marine and Environmental Science, University of Mazandaran, Babolsar, Iran H.A. Younesi Department of Marine Biology, Faculty of Marine and Environmental Science, University of Mazandaran, Babolsar, Iran M.H. Gorjian Department of Marine Biology, Faculty of Marine and Environmental Science, University of Mazandaran, Babolsar, Iran S. Khan Department of Biotechnology, Shaheed Benazir Bhutto University, Sheringal, KP, Pakistan Journal Article 2024 11 30 The main obstacles to the artificial reproduction of sturgeon can be mentioned the long-term viability of sturgeon aquaculture and the significant mortality rate of fingerlings. Microalgae supplementation has been shown in numerous studies to have a positive effect on improving overall health and survival rates in a variety of fish species larvae. This study combines the findings of other studies with the results of experimental trials to try and elucidate the mechanisms underlying the beneficial benefits of <em>Arthrospira platensis</em> on Persian sturgeon fingerlings. It also seeks to provide helpful information on the optimal dosage and administration methods for <em>A. platensis</em> supplementation in sturgeon hatcheries. During a 12-week feeding trial, 600 <em>A. persicus</em> larvae (200.50± 0.07 g), were used in this study to evaluate the effects of dietary supplementation of <em>A. platensis </em>at different concentrations (2.5%, 5%, and 7.5%, compared to a 0% control) on the growth, survival, and hemo-biochemical indices. The 7.5%<em> A. platensis</em>-fed group showed significantly higher values of white blood cells, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. The 7.5% <em>S. platensis</em>-fed group also showed a significant increase in hemoglobin levels, red blood cells, hematocrit, and mean corpuscular volume values. Regarding blood biochemical indices, a significant decrease was observed in cholesterol, triglyceride, low-density lipoprotein, lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase levels. In addition, compared to other groups, <em>A. platensis </em>at 7.5% resulted in greater serum glucose and HDL levels. In conclusion, Supplementing with <em>A. platensis </em>in a concentration of 7.5% of the diet improves the general health and stress tolerance of Persian sturgeon fingerlings, as well as their survival rates during artificial reproduction. https://jifro.areeo.ac.ir/article_132434_b762c86152e219ece839fa0a0e682c3c.pdf