In order to demonstrate filtration rate of edible cockle Cerastoderma edule under different salinity and temperature conditions, two groups namely healthy and parasited with Labratrema minimus (Bucephallidae; Digenea) were compared. Results showed that the parasited ones had difficulties in adaptation to the extreme conditions of salinity and temperature. Our results also showed that a healthy cockle could filter 78 ml min-1g-1 Flesh Dry Weight (FDW) seawater at 200e temperature and 34% salinity while an infested one processed 15.4 ml min-1g-1 FDW under the same conditions. In low salinity, which could happen during a rainy day and low tide, the healthy cockles processed 14.5 ml min-1g-1 FDW while infested cockles filtered 18.9 ml min-1g-1 FDW. Differences were not significant, however. Filtration rate of healthy cockles at a constant salinity but high temperature was 101.9 ml min-1g-1 FDW while the infested ones rated 27.2 ml min-1g-1 FDW. There was not a significant difference between their filtration rates at 20oC and 30oC. Our results showed that the parasited cockles were unable to adapt to extreme conditions when an increase in temperature or a decrease in salinity occurred. If these results could be extrapolated to natural situations, the ecological cause of mortality due to parasites could be proved and explained.